Buprenorphine (implant)
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What is the most important information I should know about buprenorphine?
Inserting and removing buprenorphine implants can cause serious or life-threatening complications.
Talk to your doctor about the risks and benefits of using this medication. Read all patient information, medication guides, and instruction sheets provided to you.
What is buprenorphine? (a capsule that is implanted under the skin to treat addiction)
The buprenorphine implant (placed under the skin) is used to treat opioid dependence in some people whose addiction has already been controlled by other forms of drug use. The implant is intended for adults and adolescents who are at least 16 years old.
Buprenorphine implants are only available from an approved pharmacy under a special program. Do not use buprenorphine implants as a pain reliever.
Buprenorphine implants may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before using buprenorphine?
You should not use the implants if you are allergic to buprenorphine.
Tell your doctor if you have ever had:
Breathing problems, sleep apnea.
Liver disease;
Gallbladder or thyroid problems.
Enlarged prostate, urination problems.
Addison’s disease (adrenal gland disorder).
An abnormal curvature of the spine that affects breathing.
head injury, brain tumor, or spinal cord problems;
Mental illness or psychosis.
alcoholism. or
Skin problems such as scars or unusual growths.
If you use buprenorphine during pregnancy, your baby may become dependent on the medicine. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on buprenorphine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Buprenorphine can pass into breast milk and may cause drowsiness or breathing problems in a nursing infant. Ask your doctor about any risks.
Buprenorphine implants are not approved for use by anyone younger than 16 years old.
How is the buprenorphine implant given? (a capsule that is implanted under the skin to treat addiction)
The buprenorphine implant is a 1-inch rod that is inserted through a needle (under local anaesthesia) into the skin of your upper arm. You will receive a total of 4 transplants.
After the implants are inserted, your arm will be covered with two bandages. Remove the top dressing after 24 hours, but leave the smaller dressing on for 3 to 5 days. Keep the area clean and dry. Apply an ice pack to the area every two hours for the first day, leaving the ice pack on the area for 40 minutes at a time.
For at least a week, check the wound area for warmth, redness, swelling, or other signs of infection.
Call your doctor immediately if you notice any of the following symptoms after inserting the implants:
the implant sticks out of your skin or comes out on its own;
you have severe pain, itching, redness, swelling, bleeding, or irritation;
You have numbness or weakness in your arm. or
You feel short of breath.
Tell your doctor if you cannot feel the implants under your skin. Your doctor may perform medical tests or refer you to a surgeon. (Capsule implanted under the skin to treat addiction)
Buprenorphine implants can remain in place for up to 6 months and must be surgically removed. Do not attempt to remove the implants yourself.
If the implant pops out of your arm, keep it in a place where others cannot reach it. As soon as possible, return the implant to your doctor. Misuse of the pornorphine implant can cause addiction, overdose, or death, especially when a child or other person uses the implant incorrectly or without a prescription. Selling or giving away a buprenorphine implant is against the law.
Buprenorphine is only part of a complete treatment program that may also include counseling and other types of addiction support. Tell your doctor if the implants do not help improve symptoms of addiction.
Any medical provider who treats you should know that you are being treated for opioid dependence and use buprenorphine. Make sure your family members know how to provide this information in case they need to speak for you during an emergency.
What happens if I miss a dose?
Because this medication is implanted under your skin, low-level doses of buprenorphine will be delivered continuously into your body for up to 6 months.
What should I avoid while using buprenorphine?
Do not drink alcohol. Serious side effects or death can occur.
Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Avoid using any opioid pain relievers without your doctor’s approval. Opioid pain medicine will not work as well while you are using buprenorphine. Talk to your doctor about other options for pain relief.
What are the possible side effects of buprenorphine?
Get emergency medical help if you have signs of an allergic reaction: hives; Difficulty breathing Swelling of your face, lips, tongue, or throat.
Inserting or removing implants can cause serious or life-threatening complications, including damage to nerves or blood vessels. Ask your doctor about these risks.
Call your doctor at once if you have:
Symptoms of opioid withdrawal–shivering, chills, increased sweating, feeling hot or cold, runny nose, watery eyes, diarrhea, vomiting.
confusion, agitation, or other changes in your mental state;
Extreme drowsiness, difficulty concentrating.
feeling light-headed, like you might loosen up;
weak or shallow breathing, breathing that stops during sleep;
blurred vision, slurred speech, problems with walking, reflexes, or coordination; or
low cortisol levels–nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, chills, fast heart rate, muscle stiffness, tingling, loss of coordination, nausea, vomiting, or diarrhea.
Long-term use of opioid medications may affect fertility (the ability to have children) in men or women. It is not known if the effects of opioids on fertility are permanent.
Common side effects may include:
pain, itching, redness, swelling, bruising, or bleeding where the implants were inserted;
Headache and depressed mood.
Nausea, vomiting and constipation.
Back ache;
Dental pain; or
sore throat.
What other drugs will affect buprenorphine?
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medicine, heart or blood pressure medicine, seizure medicine, or medicine to treat HIV or hepatitis C.
Opioid medications can interact with many other medications and cause serious side effects or death. Make sure your doctor knows if you also use:
cold or allergy medicine, asthma/COPD medicine, or a diuretic (“water pill”);
medicines for motion sickness, irritable bowel syndrome, or an overactive bladder;
other narcotic medicine – opioid pain medicine or prescription cough medicine;
a sedative such as Valium–diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;
medicine that makes you sleepy or slows your breathing–a sleeping pill, a muscle relaxer, or medicine to treat mood disorders or mental illness; or
Medicines that affect serotonin levels in your body – a stimulant or medicine for depression, Parkinson’s disease, migraine headaches, serious infections, or nausea and vomiting.
This list is not complete. Other drugs may interact with buprenorphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide
